Targeting Type 1 Adenylyl Cyclase in a Mouse Model of Fragile X Syndrome
Friday, January 19, 2018
Hongbing Wang, Professor; Department of Physiology
" Targeting Type 1 Adenylyl Cyclase in a Mouse Model of Fragile X Syndrome "
The Wang lab investigates the cellular and molecular mechanisms underlying synaptic modification and certain aspects of adaptive behavior. We aim to understand the function of calcium-stimulated signal transduction pathways and G protein-coupled receptors. We use molecular and cellular, transgenic, electrophysiological, and behavioral approaches to identify the molecular components involved in memory formation, anxiety, depression, behavioral flexibility, and emotional stability. Some results from these efforts have led to the development of new animal models of Schizophrenia and Bipolar disorder. Our mechanistic studies have also suggested several potential therapeutic approaches to treat Fragile X Syndrome and possibly autism.